FORMULATION AND IN VITRO CHARACTERIZATION OF THIOCOLCHICOSIDE PRONIOSOMES FOR ORAL DELIVERY

Objective: The main objective of the present study was to develop a controlled release formulation proniosomes thiocolchicoside. Methods: formulations were prepared with thiocolchicoside varying Span 60 and cholesterol ratio in range 4.5:1–1:4.5 using sucrose stearate as carrier by slurry method. different proniosomal characterized for micromeritic properties further %Entrapment efficiency, %Drug content, loading efficiency also determined. best optimized F8 particle size distribution, zeta potential, scanning electron microscopy, vitro dissolution studies, kinetics determine pattern drug from formulation. Further, formulated subjected stability studies. Results: Fourier-transform infrared spectroscopy showed no interaction between drugs other excipients. entrapment found within 49.71–83.62%. studies which 94.30% 24 h when compared pure drug. Kinetic analysis profiles that followed Korsmeyer–Peppas model (R2=0.9413) resulted release. mean potential proniosome derived niosomes be 118.34 nm polydispersity index 14.9% −36.8, respectively, has reasonably good characteristics well. Conclusion: Proniosomal may used delivery system oral administration. Hence, could act promising alternative option delivery.